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Antidepressants have a wide range of molecular mechanisms of action. Antidepressants are amphiphilic chemicals, which allow them to easily pass across the cell membrane and influence molecules on the outer and inner membrane surfaces, as well as cytoplasmic and nuclear molecules, Depressed persons may lose interest in once-pleasurable activities or experience cognitive problems (e.g., difficulty concentrating, remembering details, making decisions). They may think about or attempt suicide. Their weight might fluctuate considerably. Insomnia, excessive sleeping, sleep pattern changes (e.g., waking up in the middle of the night or early in the morning and being unable to fall asleep again), weariness, lack of energy, and aches, pains, or digestive disorders that are resistant to therapy may be present. Depressed mood is a normal reaction to some life experiences, a sign of many medical diseases (for example, Addison's disease, hypothyroidism), and a hallmark of several mental illnesses.
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