Antidiabetic activity of methanolic extracts of Globba marantia in Streptozotocin induced diabetic rats

Abstract

Globba marantia, a broadly practiced plant  species in India, has tremendous nutritional value as it has vital food ingredients  having therapeutic potential  to combat  rheumatism, snake bites, and disorders caused due to microbial infection. In current investigation , we studied  the antidiabetic potential of  methanol extracts of leaves of G. marantia  in streptozotocin (STZ)-stimulated  diabetic albino rats. Rats  were administrated with streptozotocin  to induce diabetes and further treated with   300 mg⁄ kg plant extract  for 3 weeks  to observe the reduction in diabetes  by observing  variations  in biochemical parameters in the serum and pancreatic tissue. Phytochemical screening revealed the presence of various metabolites. The succession of diabetes was tremendously decreased after administration of plant extracts. In rats administrated with plant dose , there was  noteworthy decrease  in serum glucose and nitric oxide, with simultaneous enhance  in serum insulin and protein concentrations. Furthermore, plant extracts  enhanced  free radical scavenging potential  in pancreatic tissue, with simultaneous reduction  in concentration  of thiobarbituric acid-reactive molecules. Histological observation of the pancreas from diabetic rats revealed  degenerative variations  in β-cells.  In mice treated with plant extracts  showed  the histoarchitectural rejuvenation  in  islets cells.   Thus we assumed that G. marantia  possessed  tremendous  antidiabetic and antioxidant potential  and some phytochemical may be isolated  for analysis  in future clinical trials.