Evaluate the Outcome of Mortality and Clinical Endpoints of Cardiac Rehabilitation and Statin Therapy after Acute Coronary Syndrome and Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis

Abstract

Background and aim:In the present study, we tried to provide sufficient evidence to evaluate the effectiveness of Cardiac Rehabilitation in patients with coronary artery disease after Acute Coronary Syndrome and Coronary Artery Bypass Grafting. Therefore, the present study was conducted to evaluate the Outcome of Mortality and Clinical Endpoints of Cardiac Rehabilitation and Statin Therapy after Acute Coronary Syndrome and Coronary Artery Bypass Grafting.

Method: From the electronic databases, PubMed, Scopus, Web of Science, EBSCO and Embasehave been used to perform a systematic literature over the last ten years between 2011 and May 2021. Newcastle-Ottawa Scale and Cochrane Collaboration’s toolused to assess quality of the cohort studies andrandomized control trial studies, respectively. Hazard ratio with 95% confidence interval, fixed effect model and Mantel-Haenszelmethod were calculated. The Meta analysis have been evaluated with the statistical software Stata/MP v.16 (The fastest version of Stata).

Result: In the first step of selecting studies 904 studies were selected to review the abstracts, in the second step, the full text of 168 studies was reviewed. Finally, thirteen studies were selected. Hazard ratio of Total mortality after Acute Coronary Syndrome and Coronary Artery Bypass Grafting between Cardiac Rehabilitation group and no-Cardiac Rehabilitationgroup  was 1.33 (HR, 1.33 95 % CI 1.20, 1.46; p=0.00)and  0.52 (HR, 0.52 95 % CI 0.33, 0.71; p=0.00), respectively.

Conclusion: mortality was reduced in Cardiac Rehabilitation after Acute Coronary Syndrome and Coronary Artery Bypass Grafting.