Effective of Photobiomodulation in Periodontitis Treatment: A Systematic Review and Meta-Analysis

Abstract

Aim: The aim of current study was evaluate the effective of photobiomodulation in periodontitis treatment.

Method: A search of the PubMed, Scopus, Web of Science, EBSCO and Embase electronic databases have been used to perform a systematic literature until August 2021. The quality of the randomized control trial studies included was assessed using the Cochrane Collaboration’s tool. 95% confidence interval for mean difference with fixed effect model and Inverse-variance method were calculated. Meta-analysis was performed using Stata/MP v.16 software (The fastest version of Stata).

Result:In the initial review, duplicate studies were eliminated and abstracts of 531 studies were reviewed. The full text of 112 studies was reviewed by two authors, finally, nine studies were selected. Mean differences of wound healing between control group and photobiomodulation group was 1.05 (MD, 1.05 95% CI 0.70, 1.40. P=0.00). Risk ratio of bleeding on probing and Probing depth between test and control group was 0.24 (RR, 0.24 95% CI –0.10, 1.10.580. P>0.05) and 2.56 (MD, 2.56 95% CI 2.40, 2.72. P>0.05), respectively.

Conclusion: photobiomodulation can play an effective role on Wound healing, Wound epithelialization, bleeding on probing, probing depth, Loss of clinical attachment level.