Anti-Rheumatoid Arthritic and Inflammatory property of Quisqualis indica Linn in wistar rat

Abstract

In India, Quisqualis indica major has a long history of medicinal usage. There aren't many reports on Quisqualis indica’s anti-arthritic properties, though. Using Complete Freund's Adjuvant (CFA)-induced arthritis generated in female Wistar rats, the anti-arthritic effects of an n-methanolic extract of Quisqualis indica (MQI) were examined. As a positive control, diclofenac was utilized. MQI activity was determined by measuring the amount of paw edema, and neutrophils. Different phytoconstituents of Quisqualis indica and antioxidant activity were also examined. Diclofenac and the MQI extract both reduced paw oedema by 18 %, 14%, and 15 % at dosages of 150 and 300 mg/kg BW, respectively. MQI decreased the prevalence of arthritis and the arthritic index as well. The number of neutrophils significantly decreased in MQI-treated animals compared to untreated rats.