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This very aim of this paper is to examine the impact of organization design on knowledge management in Ethiopian. It is quantitatively designed. 382 academicians and academic leaders were chosen from top Ten Ethiopian Universities as respondents. Confirmatory and path analysis were implemented for the data analysis purpose. For the betterment of the model fit, model modification indices were computed. The robustness of the model was tested by statistical instruments like RMR, GFI, AGFI, PGFI, NFI, RFI, IFI, TLI, CFI, and RMSEA. Empirical evidence indicated that there is strong association between organization structure, knowledge management and internal process. Moreover, statistical findings also revealed that organization structure is passive to directly and strongly affect knowledge management unless mediated by effective internal process. Hence, officials in Ethiopian universities should pay attention to align the very ideas of organization structure, internal process and knowledge management. Practical policies, strategies systems and programs should be articulated to facilitate the alignment
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