Antidiabetic activity of extract of Pterocarus santalinus Linn. Seeds on Stretozotocin diabetic rats

Abstract

The goal of the research purpose was to look into the hypoglycemic and hypolipidemic activity of ethanolic extract of seeds of pterocarpous santainus (EESPS), as well as to study it effects on liver and kidney function in diabetic rats induced with streptozotocin (STZ). Thirty male Wistar rats were divided into six groups (n=6) for this experiment. A single dose of STZ at 40mg was used to cause diabetes in four groups Biochemical markers such as total cholesterol, triglycerides, low and high density lipoprotein cholesterol, and fasting blood sugar (FBS) levels were examined on the final day of treatment. In addition, indicators of liver and kidney function were examined, including Glutamic oxaloacetic transaminase, Glutamicpyruvic transaminase, Alkaline Phosphatase, serum creatinine, and urea levels. After 42 days of treatment, blood sugar levels and triglycerides were found to be significantly lower, indicating that the ethanolic extract at 400 mg/kg body weight (b.w) was influenced significant anti-diabetic efficiency. The HDL levels increased while total cholesterol and LDL levels decreased. Furthermore, the ethanolic extract restored near-normal levels of a major hepatic and renal marker, it indicates that it protects against STZ-induced liver and kidney damage, as well as a rise in body weight Treatment with EESPS decreased the pancreatic damage caused by STZ and accelerated -cell regeneration in diabetic rats, according to histopathological study of the pancreas. The current findings point to EESPS's anti-hyperglycemic properties as well as its therapeutic potential. In conclusion Phenols and flavonoid molecules including ferulic acid, umbelliferone, and quercetin may play a key part in the mechanism of action of the EESPS. The extract can manage hyperglycemia and diabetes complications, and it has hypolipidimic activity, according to the findings of this study.