Evaluation Mandibular Advancement Surgeries For Pediatric Obstructive Sleep Apnea: A Systematic Review And Meta-Analysis

Abstract

Background and aim: Obstructive sleep apnea syndrome is a common condition in children. The aim of current Systematic Review and Meta-Analysis study was evaluation Mandibular Advancement Surgeries for Pediatric Obstructive Sleep Apnea.

Method: From the electronic databases, PubMed, Scopus, LILACS, Web of Science, EBSCO, LIVIVO, and Embase have been used to perform a systematic literature over the last ten years between 2011 and May 2021. Newcastle-Ottawa Scale and Cochrane Collaboration’s tool used to assess quality of the cohort studies and randomized control trial studies, respectively. Mean difference with 95% confidence interval (CI), fixed effect model and Inverse-variance method were calculated. Random effects were used to deal with potential heterogeneity and I² showed heterogeneity. I² values above 50% signified moderate-to-high heterogeneity. The Meta analysis have been evaluated with the statistical software Stata/MP v.16 (The fastest version of Stata).

Result: In the first step of selecting studies 4571 studies were selected to review the abstracts, in the second step, the full text of 114 studies was reviewed. Finally, eleven studies were selected. Meta-analysis reported reduction Apnea-hypopnea index, mean difference between preoperative Apnea-hypopnea index and postoperative Apnea-hypopnea index was -2.11 events/h (MD, -2.11 95% CI -2.35, -1.87; P= 0.00) among the eleven studies.

Conclusion: change in Apnea-hypopnea index after mandibular advancement surgeries was -2.11 events/h reduction. Studies with long-term outcomes are needed.