Eco-Friendly Hydrotalcite Recyclable Catalysts using Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Thiones

Abstract

Abstract

For the multi-component one-pot synthesis of dihydropyrimidinone, a hydrotalcites (HT) catalyst was used. Nitrogen-containing heterocycles are the most essential compounds in medicinal chemistry, as they exhibit a broad range of biological activities. The current study focuses on the environmentally favorable synthesis of 3,4-dihydropyrimidine-2(1H)-thione (DHPMT) in the presence of different hydrotalcite catalysts under mild conditions. Thus, prepared compounds are analysed by InfraRed spectroscopy (IR), ¹H NMR and ¹³C NMR Spectroscopy. When the compounds were tested for antibacterial activity, compound 2 performed well when compared to the normal. Higher yields, shorter reaction times, and a quicker set-up are all advantages of this green synthetic form. The easy reusability of biocompatible catalysts makes this protocol is an attractive, cost-effective and eco-friendly.