Evaluate Risk Markers For Periodontal Disease In Children With Type 1 Diabetes: A Systematic Review And Meta-Analysis

Abstract

Background and aim: It is important to evaluate the characteristics of periodontitis in children with T1D and it should be checked properly so that in the future dentists can screen children with T1D for periodontal risk markers. Therefore the aim of current Systematic Review and Meta-Analysis study was evaluate risk markers for periodontal disease in children with type 1 diabetes.

Method: From the electronic databases, PubMed, Scopus, LILACS, Web of Science, EBSCO, LIVIVO, and Embase have been used to perform a systematic literature over the last ten years between 2011 and May 2021. For Data extraction, two reviewers blind and independently extracted data from abstract and full text of studies that included.  Mean difference with 95% confidence interval (CI), fixed effect model and Inverse-variance method were calculated. The Meta analysis have been evaluated with the statistical software Stata/MP v.16 (The fastest version of Stata).

Result: 201 studies were selected to review the abstracts, the full text of 19 studies was reviewed. Finally, nine studies were selected. Mean difference of plaque index and Gingival index between children with type 1 diabetes and healthy children was (MD, 0.31 95% CI 0.24, 0.39. P=0.00) and (MD, 0.36 95% CI 0.28, 0.43. P=0.00) P =0.00), respectively.

Conclusion: The present Systematic Review and Meta-Analysis study showed that children with type 1 diabetes had higher plaque index, gingival index, bleeding on probing, and pocket depth than healthy children.