Effect Of Antihypertensive Therapy On The Level Of Fatty Tissue Hormones, Endothelium Dysfunction And Metabolic Indicators In Patients Of Arterial Hypertension With Metabolic Syndrome

Abstract

This articlepresents the effect of combined antihypertensive therapy on target blood pressure (BP), insulin sensitivity, carbohydrate and lipid metabolism, adipose tissue hormones and endothelial dysfunction of arterial hypertension (AH) with stage II with metabolic syndrome (MS).

In 95.5 % of patients achieved the target level of the BP. As a result of 12 weeks of therapy there was a decrease in body weight, increase the glycemic index, improved lipid profile, reduced leptin and increase adiponectin, improvement in endothelial function.

In patients with MS and AH along with hypotensive activity combined antihypertensive therapy has a positive effect on insulin sensitivity, lipid metabolism, adipose tissue hormones and endothelial function.