Evaluate the Efficacy and Morbidity of Biodegradable versus Titanium Osteosynthesis after Maxillofacial Trauma in Children: A Systematic Review and Meta-Analysis

Abstract

Background and aim: the researcher decided to study the efficacy and morbidity of biodegradable versus titanium osteosynthesis after maxillofacial trauma in children through a systematic review and meta-analysis.

Method: Databases of PubMed, Scopus, Web of Science, EBSCO and Embase were searched for systematic literature between 2010 to August 2021.  Newcastle-Ottawa Scale (NOS) used to assess quality of the cohort studies. For Data extraction, two reviewers blind and independently extracted data from abstract and full text of studies that included.95% confidence interval for risk ratio with fixed effect model and Mantel-Haenszel method were calculated. To deal with potential heterogeneity, random effects were used and I² showed heterogeneity. Meta-analysis was performed using Stata/MP v.16 software (The fastest version of Stata).

Result:In the initial review, duplicate studies were eliminated and abstracts of 226 studies were reviewed, the full text of 74 studies was reviewed by two authors, finally, eight studies were selected.  Risk ratio of malunion (6-12 weeks follow-up) between biodegradable and titanium group was -0.67 (RR, -0.67 95% CI -3.79, 2.46); Risk ratio of infection (12 weeks follow-up) between biodegradable and titanium group was -0.53 (RR, -0.53 95% CI -1.68, 0.61). Risk ratio of Abscess (>12 weeks follow-up) between biodegradable and titanium group was 0.24 (RR, 0.24 95% CI -1.81, 2.28).

Conclusion: Based on the findings of the present meta-analysis, no significant differences were observed in the efficacy and morbidity of biodegradable versus titanium osteosynthesis after maxillofacial trauma in children.