N-[(1h-Indol-3-Yl)Methylene]-Substituted Aniline Derivatives As Schiff’s Bases: Design, Green Synthesis Using Amla Water & In-Silico Molecular Docking Studies

Abstract

N-[(1H-indol-3-yl)-methylene]-substituted aniline derivatives as schiff’s bases were developed using a amla water-based green synthesis technique. Novel Schiff's base compound was developed through the condensation of reaction of indole-3-aldehyde and aromatic amines in presence of amla water extract as acid catalyst. Aqueous amla extract (pH 3.4) of the E. officinalis fruits considered as amla water, used as catalyst for the development of schiff bases. Aqueous extract of E. officinalis fruits (amla water) is acidic due to presence of organic acids and hence considered as an acid catalyst for the synthesis of Schiff”s bases. Physical and spectral analysis were used to describe the produced schiff’s base compounds. Molecular docking studies using AutoDock software on the developed schiff's base compound exhibits significant binding interactions with the active site region of cyclooxegenase-1 (PDB ID: 3KK6), and cyclooxegenase-2 (PDB ID: 3LN1), in comparison to standard ligand.